Orange is a high school romance series, which in itself is not usually something I'd watch. But it also has a time-travel hook, and deals with the subject of suicide and the regrets of those left behind. (Minor spoilers below, though I don't think they'd detract from anyone's enjoyment of the series.)
The time-travel bit is what drew my attention to Orange in the first place. A high school girl named Kaho gets a letter from her 10-years-in-the-future self, giving instructions about how to avoid the thing she most regrets. The mechanics of how the actual letter delivery across time happens are pretty weak, but that's not really the point. The focus is on what future knowledge does to her actions and relationships. (Note for those who aren't Japanese-literate: make sure you get version that has English translations of the letters. They're often just shown, not read aloud. Some English dubs don't have the written translations and that really detracts from this particular series. Personally, I think the sub-titles are better than dubs anyway.)
Just a few episodes in, it's revealed that future Kaho's main regret is the death of Kakeru, a new student in her class. At first they don't specify that it's a suicide, but I thought it was pretty obvious almost immediately. The rest of the series follows the efforts Kaho makes to change that future.
There's a lot of awkward teenage romance in Orange: Kaho and Kakeru, a triangle with her friend Suwa, interfering friends, and so on. The romantic tension is largely driven by how shy and easily embarrassed Kaho is. Not really my favorite thing, but it was worth tolerating for the other aspects of the show.
What I found most impressive about Orange was how Kakeru is portrayed. He comes from a broken home, loses his mother, and withdraws from personal relationships and activities (such as soccer club). He's depressed, blames himself for his mother's death, and eventually becomes suicidal. But he doesn't show any of this in day-to-day activities, continuing normal life right up into the end. In the original timeline, where the future letter originates, no one noticed and took action. That's a realistic portrayal of how suicide can happen - my family had a recent experience along those lines, and so this story really hit home.
In Orange, the future letter gives Kaho and her friends a chance to save Kakeru. There are some specifics in the letter, of course, but the most important thing is that they recognize his situation. Even when their actions have changed things so that the future knowledge doesn't make much sense in terms of specific events, the fact that they're aware of Kakeru's pain and depression puts them in a position to help. And that's what I hope people take from this story...that recognizing someone's suffering and doing everything you can for them can make a difference.